Long-term outcomes of modern multidisciplinary management of sinonasal cancers: The M. D. Anderson experience.
|
| Abstract | PURPOSE: To report long-term outcomes of modern radiotherapy for sinonasal cancers. METHODS AND MATERIALS: A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS). RESULTS: Three hundred and eleven patients were included, with median follow-up of 75 months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten-year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non-nasal cavity tumor site, T3-4 stage, neck dissection, and radiation dose were predictive of PFS, while age, non-nasal cavity tumor site, T3-4 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade ≥3 toxicities. CONCLUSION: This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.
|
|---|---|
| Authors | Houda Bahig, Hanna Y Ehab, Adam S Garden, Sweet Ping Ng, Steven J Frank, Theresa Nguyen, Gary B Gunn, David I Rosenthal, Clifton D Fuller, Renata Ferrarotto, Diana Bell, Shirley Su, Jack Phan |
| Journal | Head & neck (Head Neck) Vol. 45 Issue 7 Pg. 1692-1703 (07 2023) ISSN: 1097-0347 [Electronic] United States |
| PMID | 37165701 (Publication Type: Journal Article) |
| Copyright | © 2023 Wiley Periodicals LLC. |
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!