Induction Chemotherapy

Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.

Also Known As:

Networked: 5464 relevant articles (694 outcomes, 1148 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Ma, Jun: 53 articles (01/2022 - 02/2005)
2.	Sun, Ying: 40 articles (01/2022 - 10/2015)
3.	Chen, Lei: 34 articles (01/2022 - 10/2015)
4.	Mai, Hai-Qiang: 31 articles (01/2022 - 02/2005)
5.	Vokes, Everett E: 29 articles (01/2022 - 02/2001)
6.	Li, Wen-Fei: 27 articles (01/2022 - 10/2015)
7.	Tang, Ling-Long: 26 articles (01/2022 - 11/2016)
8.	Mao, Yan-Ping: 22 articles (01/2022 - 04/2016)
9.	Chen, Qiu-Yan: 21 articles (01/2022 - 10/2009)
10.	Guo, Ling: 21 articles (01/2022 - 10/2009)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2021 - "Although most patients with acute myeloid leukemia (AML) enter remission after induction chemotherapy, the risk of relapse remains considerable. " 10/01/2020 - "Although most patients with acute myeloid leukemia (AML) achieve clinical remission with induction chemotherapy, relapse rates remain high. " 03/19/2020 - "Most patients with acute myeloid leukemia (AML) achieve complete remission (CR) after induction chemotherapy, however, in some patients, the disease subsequently relapses and may lead to death. " 12/01/2019 - "Background: Approximately, one-third of adult patients with acute myeloid leukemia (AML) are refractory to initial induction chemotherapy and relapse occurs in most patients who achieve remission. " 08/01/2016 - "In acute myeloid leukemia (AML), despite the acceptance of standard intensive chemotherapy as an optimal induction regimen for all age groups, in the elderly patients, the best treatment should meet the challenge of multiple factors like age, comorbidities, and cytogenetics, making them ineligible for standard induction chemotherapy. "
2.	Neoplasms (Cancer) 01/01/2022 - "Adding hu14.18K322A to induction chemotherapy improved early objective responses, significantly reduced tumor volumes in most patients, improved end-of-induction response rates, and yielded an encouraging 3-year EFS. " 11/01/2019 - "Adding hu14.18K322A to induction chemotherapy produced early PR or better in most patients, reduced tumor volumes, improved CSs at the end of induction, and yielded an encouraging 2-year EFS. " 01/01/2011 - "Trimodal therapy for Pancoast tumors, consisting of induction chemotherapy and radiotherapy and subsequent surgical treatment of the tumor, currently provides the best results in terms of resectability and survival." 03/01/1995 - "These results indicate that patients whose tumors have the best pathologic response to induction chemotherapy experience the best outcome." 08/01/1992 - "The findings suggest that response of neck nodes should be assessed independently of primary tumor response in trials of organ preservation strategies using induction chemotherapy, and that failure to achieve a clinical complete response in the neck warrants planned early salvage neck dissection in order to achieve improved overall survival."
3.	Nasopharyngeal Carcinoma 01/01/2021 - "Patients with locoregionally advanced nasopharyngeal carcinoma have a high risk of disease relapse, despite a high proportion of patients attaining complete clinical remission after receiving standard-of-care treatment (ie, definitive concurrent chemoradiotherapy with or without induction chemotherapy). " 01/01/2022 - "Induction chemotherapy followed by concurrent chemoradiotherapy (IC-CCRT) may be beneficial for nasopharyngeal carcinoma. " 01/01/2022 - "In conclusion, induction chemotherapy before concurrent chemoradiotherapy improved OS significantly in patients with locally advanced nasopharyngeal carcinoma, without increasing the risk of late toxicities. " 01/01/2019 - "Induction chemotherapy added to chemoradiotherapy significantly improved recurrence-free survival and overall survival, as compared with chemoradiotherapy alone, among patients with locoregionally advanced nasopharyngeal carcinoma. " 11/01/2016 - "Addition of TPF induction chemotherapy to concurrent chemoradiotherapy significantly improved failure-free survival in locoregionally advanced nasopharyngeal carcinoma with acceptable toxicity. "
4.	Leukemia 02/01/2002 - "Complete remission was achieved by induction chemotherapy, but as myeloid/NK cell precursor acute leukemia is reported to have an extremely poor prognosis due to frequent relapse, the patient underwent allo PBSCT from her HLA-identical father, together with a myeloablative conditioning regimen. " 07/01/2019 - "Obese patients have similar rates of complete remission compared to nonobese patients following induction chemotherapy in acute leukemia. " 01/01/2013 - "The literature reports a high relapse rate and poor prognosis when treated with leukemia-type induction chemotherapy alone; however, long-term remission is attainable with allogeneic stem cell transplantation in the first complete remission. " 11/01/2006 - "Older patients with AML are less likely to achieve complete remission after induction chemotherapy, and they suffer from higher rates of leukemia relapse compared to younger cohorts. " 08/01/2006 - "Complete remission (CR) was achieved with induction chemotherapy for acute leukemia. "
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2005 - "The aim of our study was to find which progenitor cells are most suitable for the preparation of dendritic cells in acute lymphoblastic leukemia (ALL) in pediatric patients, whether blasts from bone marrow or dendritic cells generated from peripheral blood mononuclear cells taken at the time of remission after induction chemotherapy. " 05/01/1997 - "Studies in the last decade show that most adults with acute lymphocytic leukemia (ALL) can achieve remission with intensive induction chemotherapy. " 05/30/2017 - "Relapse is the major cause of treatment-failure in adults with B-cell acute lymphoblastic leukemia (ALL) achieving complete remission after induction chemotherapy. " 05/01/2003 - "The prognosis of early and very early relapse in acute lymphoblastic leukemia of childhood is still very poor unless a hematopoietic stem cell transplant is performed if a second remission can be achieved by induction chemotherapy. " 01/01/2023 - "Despite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Cytarabine (Cytosar-U)
3.	Docetaxel (Taxotere)
4.	Fluorouracil (Carac)
5.	Daunorubicin (Cerubidine)
6.	Cyclophosphamide (Cytoxan)
7.	Vincristine (Oncovin)
8.	Anthracyclines
9.	Carboplatin (JM8)
10.	Granulocyte Colony-Stimulating Factor (G-CSF)

Related Therapies and Procedures

1.	Chemoradiotherapy
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Therapeutics
5.	Adjuvant Chemotherapy