Abstract | BACKGROUND: METHODS: Eighty patients with ACHBLF were divided into group glucocorticoid (GC) and group conservative medical (CM). Sixty patients with chronic hepatitis B (CHB), and Thirty healthy controls (HCs) served as control group. SOCS1 methylation levels in peripheral mononuclear cells (PBMCs) was detected by MethyLight. RESULTS: SOCS1 methylation levels were significantly higher in patients with ACHBLF than those with CHB and HCs (P < 0.01, respectively). Nonsurvivors showed significantly higher SOCS1 methylation levels (P < 0.05) than survivors in both GC and CM groups in ACHBLF patients. Furthermore, the survival rates of the SOCS1 methylation-negative group were significantly higher than that of the methylation-positive group at 1 month (P = 0.014) and 3 months (P = 0.003) follow-up. Meanwhile, GC group and CM group had significantly lower mortality at 3 months, which may be related to application of glucocorticoid. In the SOCS1 methylation-positive group, the 1-month survival rate was significantly improved, which may be related to GC treatment (P = 0.020). However, no significant difference could be observed between the GC group and CM group in the methylation-negative group (P = 0.190). CONCLUSIONS: GC treatment could decrease the mortality of ACHBLF and SOCS1 methylation levels might serve as prognostic marker for favorable response to glucocorticoid treatment.
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Authors | Feng Li, Ying Zhang, Zhao-Hui Wang, Shuai Gao, Yu-Chen Fan, Kai Wang |
Journal | Clinical epigenetics
(Clin Epigenetics)
Vol. 15
Issue 1
Pg. 79
(05 06 2023)
ISSN: 1868-7083 [Electronic] Germany |
PMID | 37149648
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Glucocorticoids
- SOCS1 protein, human
- Suppressor of Cytokine Signaling 1 Protein
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Topics |
- Humans
- Hepatitis B, Chronic
(drug therapy, genetics)
- Glucocorticoids
(therapeutic use)
- DNA Methylation
- Prognosis
- Acute-On-Chronic Liver Failure
(genetics, complications)
- Suppressor of Cytokine Signaling 1 Protein
(genetics)
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