Abstract | BACKGROUND: METHODS: In this observational study, ninety consecutive patients treated with CAR-T underwent baseline cardiac investigation with electrocardiogram (ECG), transthoracic echocardiogram (TTE), troponin-I, and B-type natriuretic peptide (BNP). Follow-up ECG, troponin-I and BNP were obtained five days post- CAR-T. In a subset of patients (N = 53), serum inflammatory cytokines interleukin (IL)-2, IL-6, IL-15, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor ( GM-CSF), and angiopoietin 1 & 2 were tested serially, including baseline and daily during hospitalization. Adverse cardiac events were defined as new-onset cardiomyopathy/ heart failure, acute coronary syndrome, arrhythmia and cardiovascular death. RESULTS: CONCLUSION: TWEET BRIEF HANDLE:
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Authors | Dae Hyun Lee, Sanjay Chandrasekhar, Michael D Jain, Rahul Mhaskar, Kayla Reid, Sae Bom Lee, Salvatore Corallo, Melanie J Hidalgo-Vargas, Abhishek Kumar, Julio Chavez, Bijal Shah, Aleksandr Lazaryan, Farhad Khimani, Taiga Nishihori, Christina Bachmeier, Rawan Faramand, Michael G Fradley, Daniel Jeong, Guilherme H Oliveira, Frederick L Locke, Marco L Davila, Mohammed Alomar |
Journal | Cardio-oncology (London, England)
(Cardiooncology)
Vol. 9
Issue 1
Pg. 18
(Apr 01 2023)
ISSN: 2057-3804 [Electronic] England |
Vernacular Title | Authors and Affiliation. |
PMID | 37005652
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s). |
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