Abstract | Introduction:
Inflammation and oxidative stress contribute to diabetes pathogenesis and consequences. Therapeutic approaches for canine diabetes remain a challenge. Curcumin has anti-inflammatory and anti-oxidative effects and is beneficial for humans with diabetes mellitus (DM); however, data on its impact on canine diabetes is limited. This study aimed to evaluate the potential for causing adverse effects, anti-inflammatory effects, anti-oxidative effects and proteomic patterns of curcuminoid supplementation on canine DM. Methods: Altogether, 18 dogs were divided into two groups: DM (n = 6) and healthy (n = 12). Curcuminoid 250 mg was given to the DM group orally daily for 180 days. Blood and urine sample collection for hematological parameters, blood biochemistry, urinalysis, oxidative stress parameters, inflammatory markers and proteomics were performed every 6 weeks. Results and discussion:
|
Authors | Namphung Suemanotham, Pongsakorn Photcharatinnakorn, Boonrat Chantong, Shutipen Buranasinsup, Sataporn Phochantachinda, Walasinee Sakcamduang, Onrapak Reamtong, Tipparat Thiangtrongjit, Duangthip Chatchaisak |
Journal | Frontiers in veterinary science
(Front Vet Sci)
Vol. 9
Pg. 1057972
( 2022)
ISSN: 2297-1769 [Print] Switzerland |
PMID | 36619946
(Publication Type: Journal Article)
|
Copyright | Copyright © 2022 Suemanotham, Photcharatinnakorn, Chantong, Buranasinsup, Phochantachinda, Sakcamduang, Reamtong, Thiangtrongjit and Chatchaisak. |