Correlations between antimicrobial peptides and spectrophotometric skin color parameters in patients with basal cell carcinoma.

Abstract

BACKGROUND:

Antimicrobial peptides (AMPs) are active molecules in the human innate immune system, that participate in host defense and regulate the inflammation process. Previous reports have confirmed that antimicrobial peptides play a critical role in carcinogenesis.

OBJECTIVE:

The present study aimed to evaluate the correlations between plasma concentrations of AMPs and spectrophotometric parameters of skin color in patients with basal cell carcinoma and compare the results with those of healthy controls.

METHODS:

The plasma concentrations of cathelicidin and beta-defensin-2 in 100 patients (50 with skin cancer and 50 healthy control subjects) were measured, and skin color parameters were tested using a DermaSpectrophotometer.

RESULTS:

In patients with basal cell carcinoma, the concentrations of cathelicidin and beta-defensin-2 were significantly higher than those in healthy controls. In healthy control patients, when erythema increases, the levels of cathelicidin and beta-defensin-2 also increase. The direction of the relationship is opposite in people with basal cell carcinoma-the concentration of antimicrobial peptides decreases and the level of erythema increases.

CONCLUSION:

A significantly higher level of plasma concentrations of cathelicidin and HBD-2 are correspondent to the presence of basal cell carcinoma. Skin cancer modifies the relationship between intensity of skin erythema and the levels of cathelicidin and HBD-2. This can be related to inadequate immunological response in patients with skin cancers. New direction of research may be pioneered in searching for cytokine or mast cells disorders.

• Authors: Marta Fijałkowska, Mateusz Koziej, Bogusław Antoszewski, Aneta Sitek
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 149 Issue 9 Pg. 5697-5704 (Aug 2023) ISSN: 1432-1335 [Electronic] Germany
• PMID: 36542158 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Cathelicidins
• Antimicrobial Cationic Peptides
• Antimicrobial Peptides
• beta-Defensins

Topics

• Humans
• Cathelicidins
• Antimicrobial Cationic Peptides
• Antimicrobial Peptides
• beta-Defensins
• Skin Pigmentation
• Carcinoma, Basal Cell
• Skin Neoplasms
• Erythema