Abstract | Objective: Methods: A total of 154 patients who underwent PCNL at our hospital between October 2019 and January 2022 were retrospectively reviewed. The development of post-PCNL SIRS was the primary endpoint of the study. Univariable analysis and multivariable logistic regression analysis were performed to identify independent risk factors of post-PCNL SIRS. A nomogram was constructed using the independent risk factors, and receiver operating characteristic (ROC) curves were drawn. Results: There were 50 patients (32.5%) who developed SIRS after PCNL. In multivariate analysis, positive urine culture (odds ratio [OR], 3.556; p = 0.048), long operation time (OR, 1.011; p = 0.027), high IL-2R (OR, 1.002; p = 0.018), low percentage of CD3+ cells (OR 0.931; p = 0.006), and high white blood cell (WBC) count (OR, 1.282; p = 0.044) were independent risk factors for post-PCNL SIRS. These five significant variables were used to generate a nomogram that exhibited favorable fitting. The discrimination area under the ROC curves was 0.795. Conclusions: Patients with long operation times, positive urine cultures, high interleukin 2 receptor, high white blood cell counts, and low percentages of CD3+ cells may be at a higher risk of developing SIRS after PCNL. In these patients, cautious and comprehensive preoperative evaluations and appropriate treatment strategies should be considered.
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Authors | Yu He, Ding Xia, Yonghua Tong, Haojie Shang, Xiao Liu, Ejun Peng, Qiu Huang, Kun Tang, Zhiqiang Chen |
Journal | Frontiers in immunology
(Front Immunol)
Vol. 13
Pg. 1017219
( 2022)
ISSN: 1664-3224 [Electronic] Switzerland |
PMID | 36505430
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 He, Xia, Tong, Shang, Liu, Peng, Huang, Tang and Chen. |
Chemical References |
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Topics |
- Humans
- Nephrolithotomy, Percutaneous
(adverse effects)
- Retrospective Studies
- Receptors, Interleukin-2
- Systemic Inflammatory Response Syndrome
(etiology)
- Nomograms
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