Abstract | BACKGROUND: OBJECTIVES: To investigate the impact of AnxA6 polymorphism on lipid profiles and the expression of AnxA6 protein in both peripheral blood mononuclear cells (PBMCs) and lipometabolism in psoriasis. METHODS: RESULTS: The CC genotype carriers of rs11960458 had a lower expression of AnxA6 and lower levels of the pro-atherogenic lipids TC, LDL, and ApoB compared to TC genotype carriers. MTX significantly downregulated the levels of the anti-atherogenic lipids HDL-C and ApoA1 and the level of AnxA6 in TC genotype carriers, as well as the level of TGs in CC genotype carriers. CONCLUSIONS: The polymorphism of AnxA6, rs11960458, was statistically associated with the levels of pro-atherogenic lipids and with the downregulation of MTX on the levels of anti-atherogenic lipids and TGs in psoriasis.
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Authors | Fuxin Zhang, Ling Han, Bing Wang, Qiong Huang, Nikhil Yawalkar, Zhenghua Zhang, Kexiang Yan |
Journal | Journal of clinical medicine
(J Clin Med)
Vol. 11
Issue 23
(Nov 29 2022)
ISSN: 2077-0383 [Print] Switzerland |
PMID | 36498634
(Publication Type: Journal Article)
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