Calcium Hydride-Based Dressing to Promote Wound Healing.

Abstract

Wound microenvironment with excess reactive oxygen species (ROS) can significantly inhibit wound healing. Encouraged by hydrogen molecules (H2 ) with effective ROS scavenging and calcium hydride (CaH2 ) with sufficient H2 supply, the authors for the first time employed CaH2 as a therapeutic H2 donor and starch as a diluent to construct CaH2 pulvis dressing for wound healing treatment. It has been found that CaH2 by generating H2 exhibited excellent ROS scavenging performance, favorable for preserving the oxidative-stress-induced cell death. After being applied onto the skin wound, the CaH2 pulvis dressing with the unique ROS-scavenging ability can accelerate skin wound healing in healthy/diabetic mice (small animal models) and Bama mini-pigs (large animal model). Such CaH2 dressing can release H2 to relieve the inflammation levels, decrease the secretion of pro-inflammatory cytokines, increase the infiltration of inflammation-suppressive immune cells, and promote the regeneration of new blood vessels and collagens, thereby accelerating wound healing. This work highlighted that the integration of anti-oxidation and anti-inflammation functions based on CaH2 dressing endowed it with a promising possibility for the treatment of inflammatory diseases.

• Authors: Fei Gong, Nailin Yang, Jiachen Xu, Xiaoyuan Yang, Kailu Wei, Linqian Hou, Bo Liu, He Zhao, Zhuang Liu, Liang Cheng
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 12 Issue 2 Pg. e2201771 (01 2023) ISSN: 2192-2659 [Electronic] Germany
• PMID: 36226993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley-VCH GmbH.

Chemical References

• Calcium
• Reactive Oxygen Species
• Hydrogels

Topics

• Mice
• Animals
• Swine
• Calcium
• Reactive Oxygen Species (metabolism)
• Diabetes Mellitus, Experimental
• Swine, Miniature (metabolism)
• Wound Healing
• Bandages
• Hydrogels (pharmacology)