HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during Aeromonas Hydrophila infection in grass carp (Ctenopharyngodon Idella).

Abstract
In recent years, mannose oligosaccharide (MOS) as a functional additive is widely used in aquaculture, to enhance fish immunity. An evaluation of the effect of dietary MOS supplementation on the immune barrier function and related signaling molecules mechanism of grass carp (Ctenopharyngodon idella) was undertaken in the present study. Six diets with graded amounts of MOS supplementation (0, 200, 400, 600, 800, and 1000 mg/kg) were fed to 540 grass carp over 60 days. To examine the immune response and potential mechanisms of MOS supplementation on the intestine, a challenge test was conducted using injections of Aeromonas hydrophila for 14 days. Results of the study on the optimal supplementation with MOS were found as follows (1) MOS enhances immunity partly related to increasing antibacterial substances content and antimicrobial peptides expression; (2) MOS attenuates inflammatory response partly related to regulating the dynamic balance of intestinal inflammatory cytokines; (3) MOS regulates immune barrier function may partly be related to modulating TLRs/MyD88/NFκB and TOR/S6K1/4EBP signalling pathways. Finally, the current study concluded that MOS supplementation could improve fish intestinal immune barrier function under Aeromonas hydrophila infected conditions.
AuthorsZhi-Yuan Lu, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Shu-Wei Li, Cheng-Bo Zhong, Xiao-Qiu Zhou
JournalFrontiers in immunology (Front Immunol) Vol. 13 Pg. 1010221 ( 2022) ISSN: 1664-3224 [Electronic] Switzerland
PMID36177013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022 Lu, Feng, Jiang, Wu, Liu, Jiang, Kuang, Tang, Li, Zhong and Zhou.
Chemical References
  • Anti-Bacterial Agents
  • Cytokines
  • Fish Proteins
  • Mannans
  • Myeloid Differentiation Factor 88
  • Oligosaccharides
  • Mannose
Topics
  • Aeromonas hydrophila (physiology)
  • Animal Feed (analysis)
  • Animals
  • Anti-Bacterial Agents
  • Carps (metabolism)
  • Cytokines (metabolism)
  • Diet
  • Dietary Supplements
  • Fish Diseases
  • Fish Proteins (metabolism)
  • Gram-Negative Bacterial Infections (veterinary)
  • Immunity, Innate
  • Intestines
  • Mannans
  • Mannose
  • Myeloid Differentiation Factor 88 (metabolism)
  • Oligosaccharides

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: