Evaluation of the potential of Rejuveinix plus dexamethasone against sepsis.

Abstract	Aim: Our main objectives were to compare the effects of Rejuveinix (RJX), dexamethasone (DEX) and their combination on the severity of sepsis and survival outcome in an animal model of fatal sepsis. Methods: We used the LPS plus D-galactosamine mouse model of sepsis to compare the anti-inflammatory activities of RJX, dexamethasone and a combination of RJX plus DEX. Additionally, we examined the clinical feasibility and tolerability of combining RJX with DEX in COVID-19 patients in a clinical phase I study. Data were analyzed using standard methods. Results & conclusion: RJX exhibited potent anti-inflammatory activity in the murine sepsis model. The combination of RJX plus DEX was more effective than either agent alone, decreased the inflammatory cytokine responses and associated organ damage, and improved the survival outcome in mice. In the phase I clinical study, RJX plus DEX was well tolerated by COVID-19 patients.
Authors	Fatih M Uckun, Muhammad Saeed, Mustafa Awili, Ibrahim H Ozercan, Sanjive Qazi, Cynthia Lee, Adeel Shibli, Alan W Skolnick, Alonso Prusmack, Joseph Varon, Cesar Ip Barrera, Cemal Orhan, Michael Volk, Kazim Sahin
Journal	Future microbiology (Future Microbiol) Vol. 17 Pg. 1217-1229 (Oct 2022) ISSN: 1746-0921 [Electronic] England
PMID	36052743 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents Drug Combinations ascorbic acid, magnesium sulfate heptahydrate, cyanocobalamin, thiamine hydrochloride, riboflavin 5' phosphate, niacinamide, pyridoxine hydrochloride, and calcium D-pantothenate drug combination Pantothenic Acid Niacinamide Magnesium Sulfate Dexamethasone Pyridoxine Ascorbic Acid Riboflavin Thiamine
Topics	Animals Anti-Inflammatory Agents (therapeutic use) Ascorbic Acid Dexamethasone (therapeutic use) Disease Models, Animal Drug Combinations Magnesium Sulfate Mice Niacinamide Pantothenic Acid Pyridoxine Riboflavin Sepsis (drug therapy) Thiamine COVID-19 Drug Treatment

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