Abstract | BACKGROUND: The extent to which adverse drug reactions (ADRs) of biologics differ per immune-mediated inflammatory disease (IMID), and the relevance of tailoring ADR information per IMID is not fully investigated. We aimed to compare patient-reported ADRs attributed to adalimumab and etanercept between different inflammatory rheumatic diseases (IRDs). RESEARCH DESIGN AND METHODS: ADR reports from IRD patients were extracted from the Dutch Biologic Monitor. ADR frequencies were compared using Fischer-Freeman-Halton exact test and the influence of covariates was assessed using binomial logistic regression. RESULTS:
CONCLUSIONS: There were no differences in frequencies and nature of patient-reported ADRs attributed to adalimumab and etanercept between different IRDs. However, more research is needed to align patients' and health-care professionals' perspectives to improve knowledge on disease-specific ADRs.
|
Authors | Lieke H Roest, Leanne J Kosse, Jette A van Lint, Helen R Gosselt, Joep H G Scholl, Eugène van Puijenbroek, Harald E Vonkeman, Sander W Tas, Michael T Nurmohamed, Bart J F van den Bemt, Naomi T Jessurun |
Journal | Expert opinion on drug safety
(Expert Opin Drug Saf)
Vol. 22
Issue 3
Pg. 203-211
(Mar 2023)
ISSN: 1744-764X [Electronic] England |
PMID | 36036179
(Publication Type: Multicenter Study, Journal Article)
|
Chemical References |
- Tumor Necrosis Factor Inhibitors
- Tumor Necrosis Factor-alpha
- Adalimumab
- Etanercept
|
Topics |
- Humans
- Tumor Necrosis Factor Inhibitors
- Tumor Necrosis Factor-alpha
- Adalimumab
(adverse effects)
- Etanercept
(adverse effects)
- Prospective Studies
- Arthritis, Rheumatoid
(drug therapy)
- Drug-Related Side Effects and Adverse Reactions
- Registries
|