Abstract | AIM: This study evaluated the possible protective impact of different vintages of Hongqu rice wines on metabolic syndrome (MetS) in rats induced by high-fat/high- fructose diet (HFFD). METHODS: Rats were randomly divided into six groups and treated with (a) basal diet (13.9 kJ/g); (b) HFFD (20.0% w/w lard and 18.0% fructose, 18.9 kJ/g) and (c-f) HFFD with 3-, 5-, 8- and 15-year-aged Hongqu rice wines (9.96 ml/kg body weight), respectively, at an oral route for 20 weeks. RESULTS: Hongqu rice wines could alleviate HFFD-induced augment of body weight gain and fat accumulation, and the release of pro-inflammatory cytokines. Glycolipid metabolic abnormalities caused by HFFD were ameliorated after Hongqu rice wines consumption by lowering levels of fasting insulin, GSP, HOMA-IR, AUC of OGTT and ITT, and lipid deposition (reduced contents of TG, TC, FFA and LDL-C, and elevated HDL-C level) in the serum and liver, probably via regulating expressions of genes involving in IRS1/PI3K/AKT pathway, LDL-C uptake, fatty acid β-oxidation, and lipolysis, export and synthesis of TG. In addition, concentrations of MDA and blood pressure markers (ANG-II and ET-1) declined, and activities of antioxidant enzymes (SOD and CAT) were improved in conditions of Hongqu rice wines compared to those in the HFFD group. Eight-year-aged Hongqu rice wine produced a more effective effect on alleviating HFFD-caused MetS among different vintages of Hongqu rice wines. CONCLUSION:
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Authors | Nanhai Zhang, Fang Kong, Xiaoxuan Jing, Jingxuan Zhou, Liang Zhao, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou |
Journal | Alcohol and alcoholism (Oxford, Oxfordshire)
(Alcohol Alcohol)
Vol. 57
Issue 6
Pg. 776-787
(Nov 11 2022)
ISSN: 1464-3502 [Electronic] England |
PMID | 35922962
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2022. Medical Council on Alcohol and Oxford University Press. All rights reserved. |
Chemical References |
- Antioxidants
- Cholesterol, LDL
- Fructose
- Phosphatidylinositol 3-Kinases
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Topics |
- Animals
- Rats
- Antioxidants
(metabolism)
- Body Weight
- Cholesterol, LDL
(metabolism, pharmacology)
- Diet, High-Fat
- Fructose
- Liver
- Metabolic Syndrome
- Phosphatidylinositol 3-Kinases
(metabolism, pharmacology)
- Oryza
- Alcoholic Beverages
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