Immune thrombocytopenia is the most common autoimmune disorder involving blood types. In several studies, the role of T CD4+ cells in patients with
immune thrombocytopenia has been associated with different results. Therefore, in this study, with the aim of applied research in the pathogenesis of
immune thrombocytopenia, the relationship was investigated between the number of T CD4+ cells, serum levels of
IL-11 and
IL-17 cytokines, and platelet count. In this regard, 100 patients with
immune thrombocytopenia and 100 healthy individuals were included in the study. The T CD4+ cell counts were examined by flow cytometry and in addition, serum levels of
interleukins 11 and 17 were measured by ELISA. The results of this study showed that the number of T CD4+ cells and plasma level of
IL-17 were not significantly different between the two groups, but plasma levels of
IL-11 in the patient group were significantly higher than the control group (P = 0.286). Overall, in this study, the level of
cytokine IL-11 was significantly increased in comparison with
IL-17 and T CD4+ cells in patients with
immune thrombocytopenia, so it is suggested that measurement of
cytokine IL-11 level in these patients could be considered as a critical diagnostic marker and
indicator in the stages of
disease progression.