Abstract | INTRODUCTION: OBJECTIVES: METHODS: A total of 40 subjects was recruited from Chengdu, China which is among the top three cities in terms of respiratory mortality related to air pollution. The participants were randomly provided either placebo or curcumin supplements for 2 weeks and blood samples were collected at the baseline and at the end of the intervention to monitor systemic markers. In our follow up mechanistic study, C57BL/6 mice (n = 40) were randomly allocated into 4 groups: Control group (saline + no acrolein), Curcumin only group (curcumin + no acrolein), Acrolein only group (saline + acrolein), and Acrolein + Curcumin group (curcumin + acrolein). Curcumin was orally administered at 100 mg/kg body weight once a day for 10 days, and then the mice were subjected to nasal instillation of acrolein (5 mg/kg body weight). Twelve hours after single acrolein exposure, all mice were euthanized. RESULTS:
Curcumin supplementation, with no noticeable adverse responses, reduced circulating pro-inflammatory cytokines in association with clinical pneumonitis as positive predictive while improving those of anti-inflammatory cytokines. In the pre-clinical study, curcumin reduced pneumonitis manifestations by suppression of intrinsic and extrinsic apoptotic signaling, which is attributed to enhanced redox sensing of Nrf2 and thus sensitized synthesis and restoration of GSH, at least in part, through curcumin-Keap1 conjugation. CONCLUSIONS:
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Authors | Eun Hee Jo, Ji Eun Moon, Moon Han Chang, Ye Jin Lim, Jung Hyun Park, Suk Hee Lee, Young Rae Cho, Art E Cho, Seung Pil Pack, Hyeon-Wee Kim, Liana Crowley, Brandy Le, Aykin-Burns Nukhet, Yinfeng Chen, Yihang Zhong, Jiangchao Zhao, Ying Li, Hanvit Cha, Jeong Hoon Pan, Jae Kyeom Kim, Jin Hyup Lee |
Journal | Journal of advanced research
(J Adv Res)
Vol. 46
Pg. 17-29
(04 2023)
ISSN: 2090-1224 [Electronic] Egypt |
PMID | 35772713
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023. Production and hosting by Elsevier B.V. |
Chemical References |
- Acrolein
- Air Pollutants
- Curcumin
- Cysteine
- Cytokines
- Keap1 protein, mouse
- Kelch-Like ECH-Associated Protein 1
- NF-E2-Related Factor 2
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Topics |
- Animals
- Mice
- Acrolein
(pharmacology)
- Air Pollutants
(adverse effects, analysis)
- Apoptosis
- Body Weight
- Curcumin
(adverse effects)
- Cysteine
(adverse effects)
- Cytokines
(adverse effects)
- Kelch-Like ECH-Associated Protein 1
- Mice, Inbred C57BL
- Models, Animal
- NF-E2-Related Factor 2
(metabolism, pharmacology)
- Pneumonia
(chemically induced, drug therapy)
- Pulmonary Disease, Chronic Obstructive
(chemically induced, drug therapy)
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