Abstract | PURPOSE: METHODS: A total of 18 schizophrenic patients with the symptom of pure AHs (pAHs), 28 without AH ( nAHs) and 43 age-matched healthy persons (Con) were enrolled in this study. Participants in pAHs and nAHs groups had relapsed into exacerbations of psychosis after self-discontinuing antipsychotics for at least one month; blood samples were drawn prior to restarting anti-psychotic treatment. Participants with history of recreational substance use were excluded. Positive and Negative Syndrome Scale (PANSS) and Auditory Hallucinations Rating Scale (AHRS) were used to assess the clinical mental state of all samples. Enzyme-linked immunosorbent assay (ELISA) was used to estimate the level of cytokines, and metabolomics analysis to identify potential biomarkers and pathways in the three groups. Graphpad 8.0 software was used to calculate the area under the receiver operating characteristic (ROC) curve. The relationship between metabolites and cytokines were determined using correlation analysis. RESULTS: CONCLUSIONS: This study revealed the metabolic profile of patients with schizophrenia with AHs and provided new information to support the diagnosis. The identification of unique biomarkers would contribute to objective and reliable diagnoses of patients with schizophrenia with AH.
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Authors | Xinchun Li, Chao Yang, Xiaoli Liang, Dongfeng Li, Zhiqiang Zhou, Huiqiong Xiao, Xuejun Liu, Jie Li, Dong Yang, Meizhi Li |
Journal | Clinical and investigative medicine. Medecine clinique et experimentale
(Clin Invest Med)
Vol. 45
Issue 2
Pg. E39-48
(06 26 2022)
ISSN: 1488-2353 [Electronic] Canada |
PMID | 35752981
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Glutamates
- Interleukin-2
- Serine
- Phenylalanine
- Cystine
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Topics |
- Cystine
- Cytokines
- Glutamates
- Hallucinations
(diagnosis)
- Humans
- Interleukin-2
- Metabolomics
- Phenylalanine
- Schizophrenia
- Serine
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