Abstract | Background and aim: Experimental procedure: Two protocols of treatment were followed: intraperitoneal administration of free α- tocopherol (100 mg/kg i.p.) or oral administration of free and nanoencapsulated α- tocopherol (100 mg/kg p.o.). Animals were treated during 18 days after arthritis induction. Results: Free (i.p.) and encapsulated α- tocopherol decreased the hind paws edema, the leukocytes infiltration into femorotibial joints and the mRNA expression of pro-inflammatory cytokines in the tibial anterior muscle of arthritic rats, but the encapsulated compound was more effective. Free (i.p.) and encapsulated α- tocopherol decreased the high levels of reactive oxygen species in the brain and liver, but only the encapsulated compound decreased the levels of protein carbonyl groups in these organs. Both free (i.p.) and encapsulated α- tocopherol increased the α- tocopherol levels and the ratio of reduced to oxidized glutathione in these organs. Conclusion:
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Authors | Lucas S Moreira, Any Carolina Chagas, Ana Paula Ames-Sibin, Vanesa O Pateis, Odinei H Gonçalves, Francielli Maria S Silva-Comar, Luzmarina Hernandes, Anacharis B Sá-Nakanishi, Lívia Bracht, Ciomar A Bersani-Amado, Adelar Bracht, Jurandir F Comar |
Journal | Journal of traditional and complementary medicine
(J Tradit Complement Med)
Vol. 12
Issue 4
Pg. 414-425
(Jul 2022)
ISSN: 2225-4110 [Print] Netherlands |
PMID | 35747358
(Publication Type: Journal Article)
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