Abstract |
Gut microbiota has become a new therapeutic target in the treatment of inflammatory Bowel Disease (IBD). Probiotics are known for their beneficial effects and have shown good efficacy in the clinical treatment of IBD and animal models of colitis. However, how these probiotics contribute to the amelioration of IBD is largely unknown. In the current study, the DSS-induced mouse colitis model was treated with oral administration of Lactobacillus plantarum strains to investigate their effects on colitis. The results indicated that the L. plantarum strains improved dysbiosis and enhanced the abundance of beneficial bacteria related to short-chain fatty acids (SCFAs) production. Moreover, L. plantarum strains decreased the level of pro-inflammatory cytokines, i.e., IL-17A, IL-17F, IL-6, IL-22, and TNF-α and increased the level of anti-inflammatory cytokines, i.e., TGF-β, IL-10. Our result suggests that L. plantarum strains possess probiotic effects and can ameliorate DSS colitis in mice by modulating the resident gut microbiota and immune response.
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Authors | Israr Khan, Junshu Wei, Anping Li, Zhirong Liu, Pingrong Yang, Yaping Jing, Xinjun Chen, Tang Zhao, Yanrui Bai, Lajia Zha, Chenhui Li, Naeem Ullah, Tuanjie Che, Chunjiang Zhang |
Journal | International microbiology : the official journal of the Spanish Society for Microbiology
(Int Microbiol)
Vol. 25
Issue 3
Pg. 587-603
(Aug 2022)
ISSN: 1618-1905 [Electronic] Switzerland |
PMID | 35414032
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
Chemical References |
- Cytokines
- Dextran Sulfate
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Topics |
- Animals
- Colitis
(chemically induced, therapy)
- Cytokines
- Dextran Sulfate
- Disease Models, Animal
- Gastrointestinal Microbiome
- Immunity
- Lactobacillus plantarum
- Mice
- Probiotics
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