Abstract | BACKGROUND: METHODS:
Sarcoidosis patients from three tertiary centres were retrospectively identified by pharmacy records based on treatment with infliximab. Treatment with Infliximab was initiated in patients who failed first and second line immunomodulators as determined by a multidisciplinary team of Respirologists, Dermatologists, ENT specialists, Rheumatologists, and Neurologists. Participants were characterized by the primary organ for which infliximab was initiated and the total number of organs involved. Clinical outcomes were categorized as treatment success versus failure. We defined treatment success as (A) improvement of cutaneous, upper airway, lymph node, gastrointestinal, eye, or joint manifestations; or (B) improvement or no change in central nervous system (CNS) or pulmonary manifestations. RESULTS: 33 patients with refractory sarcoidosis were identified. The proportion of treatment success was 100% (95% CI 54.1-100) in CNS, 91.7% (95% CI 61.5-99.8) in cutaneous, 78.6% (95% CI 49.2-95.3) in pulmonary and 71.5% (95% CI 29.0-96.3) in upper airway disease. The use of infliximab was associated with a reduction prednisone dose by 50%. CONCLUSION:
|
Authors | Abdullah Sakkat, Gerard Cox, Nader Khalidi, Maggie Larche, Karen Beattie, Elisabetta A Renzoni, Nilesh Morar, Vasilis Kouranos, Martin Kolb, Nathan Hambly |
Journal | Respiratory research
(Respir Res)
Vol. 23
Issue 1
Pg. 54
(Mar 09 2022)
ISSN: 1465-993X [Electronic] England |
PMID | 35264154
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Copyright | © 2022. The Author(s). |
Chemical References |
- Glucocorticoids
- Tumor Necrosis Factor Inhibitors
- Infliximab
- Prednisone
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Dose-Response Relationship, Drug
- Drug Resistance
(drug effects)
- Female
- Follow-Up Studies
- Global Health
- Glucocorticoids
(adverse effects, therapeutic use)
- Humans
- Incidence
- Infliximab
(therapeutic use)
- Male
- Middle Aged
- Prednisone
(adverse effects, therapeutic use)
- Recurrence
- Retrospective Studies
- Sarcoidosis
(drug therapy, epidemiology)
- Time Factors
- Treatment Outcome
- Tumor Necrosis Factor Inhibitors
(therapeutic use)
|