Association of IL-22 and IL-22RA1 gene variants in Iranian patients with colorectal cancer.

Abstract

AIM:

In the current study, it was hypothesized that single nucleotide polymorphisms (SNPs) in the regulatory region of the IL-22 signaling pathway genes, including IL-22 and IL-22RA1 variants, may be associated with CRC susceptibility.

BACKGROUND:

The important role of pro-inflammatory cytokines during tumorigenesis is well-established. In recent years, IL-22 has been linked with colorectal cancer (CRC) through a number of mechanistic and observational studies.

METHODS:

The association of four polymorphisms in the IL-22 (rs1179251 and rs1179246) and IL-22RA1 (rs4648936 and rs10794665) genes with CRC risk were studied using a case-control design with 304 cases and 345 controls from the Iranian population. All 649 subjects were evaluated by PCR-RFLP method.

RESULTS:

No significant difference was found in genotype and allele frequencies between the cases and controls for either IL-22 and IL-22RA1 gene variants or CRC risk before or after adjusting for confounders.

CONCLUSION:

The current findings do not present any significant evidence for associations between variants in IL-22 signaling pathway genes and CRC. Complementary studies with greater sample sizes may be necessary to fully elucidate the nature of these associations.

• Authors: Seyed Reza Mohebbi, Khatoon Karimi, Fatemeh Rostami, Shabnam Kazemian, Pedram Azimzadeh, Hanieh Mirtalebi, Ehsan Nazemalhosseini-Mojarad, Hamid Asadzadeh Aghdaei, Reza Vafaee, Mohammad Hossain Heydari
• Journal: Gastroenterology and hepatology from bed to bench (Gastroenterol Hepatol Bed Bench) Vol. 14 Issue Suppl1 Pg. S58-S65 ( 2021) ISSN: 2008-2258 [Print] Iran
• PMID: 35154603 (Publication Type: Journal Article)
• Copyright: ©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.