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Lactiplantibacillus plantarum Y15 alleviate type 2 diabetes in mice via modulating gut microbiota and regulating NF-κB and insulin signaling pathway.

Abstract
Probiotics have been used for the treatment of chronic metabolic diseases, including type 2 diabetes (T2D). However, the mechanisms of antidiabetic effects are not well understood. The object of this study is to assess the antidiabetic effect of Lactiplantibacillus plantarum Y15 isolated from Chinese traditional dairy products in vivo. Results revealed that L. plantarum Y15 administration improved the biochemical indexes related to diabetes, reduced pro-inflammatory cytokines, L. plantarum Y15 administration reshaped the structure of gut microbiota, decreased the abundance of LPS-producing, and increased short-chain fatty acids (SCFAs)-producing bacteria, which subsequently reduce the levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines. L. plantarum Y15 administration also regulated the expressions of the inflammation and insulin signaling pathway-related genes. These results suggest that L. plantarum Y15 may serve as a potential probiotic for developing food products to ameliorate T2D.
AuthorsYin Liu, Shujuan Zheng, Jiale Cui, Tingting Guo, Jingtao Zhang
JournalBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (Braz J Microbiol) Vol. 53 Issue 2 Pg. 935-945 (Jun 2022) ISSN: 1678-4405 [Electronic] Brazil
PMID35150432 (Publication Type: Journal Article)
Copyright© 2022. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.
Chemical References
  • Cytokines
  • Hypoglycemic Agents
  • Insulin
  • Lipopolysaccharides
  • NF-kappa B
Topics
  • Animals
  • Cytokines (metabolism)
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Gastrointestinal Microbiome (physiology)
  • Hypoglycemic Agents (pharmacology)
  • Insulin (metabolism, pharmacology)
  • Lactobacillus plantarum (metabolism)
  • Lipopolysaccharides (pharmacology)
  • Mice
  • NF-kappa B (genetics, metabolism)
  • Probiotics
  • Signal Transduction

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