Over the last twenty months, the attention of the world has been focusing on managing the unprecedented and devastating wave of
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) and mitigating its impacts. Recent findings indicated that high levels of pro-inflammatory
cytokines are leading cause of poor prognosis in severely ill
COVID-19 patients. Presently, the multiple variants and highly contagious nature of virus makes challenge humongous. The shortage and vaccine hesitancy also prompted to develop
antiviral therapeutic agents to manage this pandemic. Nanocurcumin has potential
antiviral activities and also beneficial in post COVID inflammatory complications. We have developed nanocurcumin based formulation using
pyrroloquinoline quinone (PQQ) which protects cardio-pulmonary function and mitochondrial homeostasis in hypobaric
hypoxia induced
right ventricular hypertrophy in animal model and human ventricular cardiomyocytes. Nanocurcumin based formulation (NCF) with improved bioavailability, has proven several holistic
therapeutic effects including myocardial protection, and prevents
edema formation, anti-inflammatory and
antioxidant properties, maintaining metabolic and mitochondrial homeostasis under hypoxic condition. The post COVID-inflammatory syndrome also reported to cause impaired heart function,
lung injuries and increased
C-reactive protein level in severely ill patients. Thus, we speculate that NCF could be a new treatment option to manage post
COVID-19 inflammatory syndrome.