IL-23 orchestrating immune cell activation in arthritis.

Abstract

IL-23 is a cytokine member of the IL-12 superfamily. These heterodimeric cytokines offer broad immune regulatory activity with potential effector function in inflammatory arthritis. IL-23 is a pro-inflammatory cytokine secreted by dendritic cells and macrophages. It plays a key role in both innate and adaptive immunity. By promoting and maintaining T cell differentiation into Th17 T cells, IL-23 is a key player in the pathogenesis of rheumatic diseases. Data from pre-clinical IL-23 knockout models show the major importance of IL-23 in development of arthritis. The induction and maintenance of type 17 cells, which secrete IL-17A and other pro-inflammatory cytokines, contributes to local synovial inflammation and skin inflammation in PsA, and perhaps in RA. Commensurate with this, therapeutic strategies targeting IL-23 have proven efficient in PsA in several studies, albeit not yet in RA.

• Authors: Aurélie Najm, Iain B McInnes
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 60 Issue Suppl 4 Pg. iv4-iv15 (10 19 2021) ISSN: 1462-0332 [Electronic] England
• PMID: 34668017 (Publication Type: Editorial, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.

Chemical References

• Interleukin-23

Topics

• Animals
• Arthritis (drug therapy, immunology, metabolism)
• Humans
• Interleukin-23 (antagonists & inhibitors, metabolism)
• Molecular Targeted Therapy