Abstract | BACKGROUND: AIMS: This study aimed at comparing the efficacy, tolerability and safety of montelukast versus finasteride in the treatmentof moderate acne in women. PATIENTS/METHOD: This randomized, single-blinded, prospective trial over 12 weeks recruited 65 female subjects with moderate acne vulgaris (Global Acne Grading System Scale) for evaluation. One group (n = 30) received oral montelukast (10 mg PO daily), while the second group (n = 25) received oral finasteride (2.5 mg PO daily) in combination with topical clindamycin 2% solution. Lesion count and acne severity were evaluated at time intervals of 0 (baseline), 4, 8, and 12 weeks. Adverse effects of the drugs were noted. RESULTS: Both lesion count and severity of acne decreased significantly after treatment in both the groups as compared to the baseline. The acne severity score reached from 33.93 in time zero to 20.6 in the 12th week and 35.71 at baseline to 16.43 at the end of treatment in the Montelukast and Finasteride groups, respectively. Side effects were noted in 3 patients and 2 patients in the monteleukast and finasteride group, respectively, which were transient and non-serious in nature proving the satisfactory tolerability and safety of these two drugs. CONCLUSION:
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Authors | Ghasem Rahmatpour Rokni, Farzaneh Mohammadnezhad, Majid Saeedi, Shiva Shadi, Aseem Sharma, Sunmeet Sandhu, Atula Gupta, Mohamad Goldust |
Journal | Journal of cosmetic dermatology
(J Cosmet Dermatol)
Vol. 20
Issue 11
Pg. 3580-3585
(Nov 2021)
ISSN: 1473-2165 [Electronic] England |
PMID | 34648685
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2021 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC. |
Chemical References |
- Acetates
- Cyclopropanes
- Quinolines
- Sulfides
- Finasteride
- montelukast
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Topics |
- Acetates
(adverse effects)
- Acne Vulgaris
(drug therapy)
- Cyclopropanes
- Female
- Finasteride
(adverse effects)
- Humans
- Prospective Studies
- Quinolines
- Sulfides
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