Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation.

Abstract

Acute lung injury (ALI) is a respiratory disease that leads to death in severe cases. Hordenine (Hor), a barley-derived natural product, has various biological activities, including anti-inflammatory, and anti-oxidation activities. We investigated the effect of Hor on lipopolysaccharide-induced ALI and its potential mechanism. The anti-inflammatory effects of Hor were detected using in vivo and in vitro models by enzyme-linked immunosorbent assay, real-time polymerase chain reaction, western blotting, and molecular docking simulations. Hor inhibited increases in the levels of inflammatory factors both in vivo and in vitro, and its anti-inflammatory effect inhibited activation of protein kinase B, nuclear factor-κB, and mitogen-activated protein kinase signaling. Hor alleviated lipopolysaccharide-induced ALI by inhibiting inflammatory cytokine increases in vivo and in vitro and shows potential for preventing inflammatory disease.

• Authors: Xiyue Zhang, Li Du, Jinrong Zhang, Chunyan Li, Jie Zhang, Xuejiao Lv
• Journal: Frontiers in pharmacology (Front Pharmacol) Vol. 12 Pg. 712232 ( 2021) ISSN: 1663-9812 [Print] Switzerland
• PMID: 34539399 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Zhang, Du, Zhang, Li, Zhang and Lv.