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Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".

Abstract
Break et al. (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and not to autoantibodies neutralizing interleukin-17 cytokines. We argue that both claims are not conclusively supported by their data and are at odds with 35 years of study.
AuthorsAnne Puel, Jean-Laurent Casanova
JournalScience (New York, N.Y.) (Science) Vol. 373 Issue 6561 Pg. eabi5459 (Sep 17 2021) ISSN: 1095-9203 [Electronic] United States
PMID34529464 (Publication Type: Journal Article, Comment)
Topics
  • Humans
  • Mucous Membrane
  • Mycoses

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