Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats.

Abstract

Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI.

• Authors: Nursel Dikmen, Mustafa Cellat, Muhammed Etyemez, Cafer Tayer İşler, Ahmet Uyar, Tuba Aydın, Mehmet Güvenç
• Journal: Inflammation (Inflammation) Vol. 44 Issue 6 Pg. 2246-2259 (Dec 2021) ISSN: 1573-2576 [Electronic] United States
• PMID: 34515957 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Cytokines
• Inflammation Mediators
• Iridoid Glucosides
• Lipopolysaccharides
• oleuropein

Topics

• Acute Lung Injury (chemically induced, metabolism, pathology, prevention & control)
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antioxidants (pharmacology)
• Cytokines (metabolism)
• Disease Models, Animal
• Inflammation Mediators (metabolism)
• Iridoid Glucosides (pharmacology)
• Lipopolysaccharides
• Lung (drug effects, metabolism, pathology)
• Male
• Neutrophil Infiltration (drug effects)
• Oxidative Stress (drug effects)
• Rats, Wistar
• Rats