Abstract | BACKGROUND: CASE REPORT: We present an extremely rare case of a 34-year-old male with Hajdu-Cheney syndrome. The patient was admitted to the Department of Oral Surgery, Medical University of Gdańsk, in order to perform the extraction of three teeth. These teeth were not eligible for conservative treatment and prosthetic reconstruction. The patient was treated with denosumab (angiogenesis and receptor activator of nuclear factor-κB RANK ligand inhibitor, RANKL). DISCUSSION:
Denosumab is a monoclonal antibody against RANKL. This drug works through a suppression of osteoclast activity. In cases of patients in which the pathway of the RANK/RANKL/ osteoprotegerin is dysregulated, denosumab has been approved for the treatment off-label. In patients receiving denosumab, a delayed wound healing in the oral cavity and osteonecrosis may occur. Dental procedures involving the alveolar bone process ( tooth extractions and bone alveoloplasty) may be a risk factor for medication-related osteonecrosis of the jaw (MRONJ). Spontaneous osteonecrosis is rarely observed. MRONJ consists of the destruction of exposed bone, with the exposure persisting for a minimum of 6-8 weeks. This is the first article about an HCS patient treated with denosumab who underwent invasive oral surgery procedures. This case report highlights the difficulties for professionals occurring during the oral surgery procedures in such patients.
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Authors | Magdalena Kaczoruk-Wieremczuk, Paulina Adamska, Łukasz Jan Adamski, Piotr Wychowański, Barbara Alicja Jereczek-Fossa, Anna Starzyńska |
Journal | International journal of environmental research and public health
(Int J Environ Res Public Health)
Vol. 18
Issue 17
(08 28 2021)
ISSN: 1660-4601 [Electronic] Switzerland |
PMID | 34501688
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Bone Density Conservation Agents
- Denosumab
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Topics |
- Acro-Osteolysis
- Adult
- Bone Density Conservation Agents
- Denosumab
(therapeutic use)
- Hajdu-Cheney Syndrome
- Humans
- Male
- Tooth Extraction
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