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MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness.

AuthorsYahui Liu, Juan Du, Xinnan Liu, Lingbiao Wang, Yichao Han, Chunrong Huang, Rui Liang, Fang Zheng, Guochao Shi, Bin Li
JournalSignal transduction and targeted therapy (Signal Transduct Target Ther) Vol. 6 Issue 1 Pg. 321 (09 08 2021) ISSN: 2059-3635 [Electronic] England
PMID34493712 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-(2-(4-heptylphenyl)ethyl)-6-hydroxy-benzoic acid
  • Il33 protein, mouse
  • Interleukin-33
  • Salicylates
  • Histone Acetyltransferases
  • Kat8 protein, mouse
Topics
  • Acetylation (drug effects)
  • Animals
  • Asthma (drug therapy, metabolism)
  • Histone Acetyltransferases (antagonists & inhibitors, metabolism)
  • Inflammation (drug therapy, metabolism)
  • Interleukin-33 (metabolism)
  • Mice
  • Salicylates (pharmacology)

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