Diagnostic value of combined detection of IL-1β, IL-6, and TNF-α for sepsis-induced cardiomyopathy.

Abstract

INTRODUCTION:

This study aimed to explore the diagnostic value and the correlation of the combined detection of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) with sepsis-induced cardiomyopathy (SIC).

PATIENTS AND METHODS:

Admitted to our hospital from January 2017 to January 2019, 96 patients with SIC (a study group) and 90 patients with sepsis (a control group) were enrolled. The three cytokines were determined and the diagnostic value of their combined detection for SIC was analyzed.

RESULTS:

The cytokines were remarkably higher in the study group (p<.001). The combined detection of the three had a better diagnostic value for SIC (p<.001). The three cytokines were independent risk factors for the death of patients with SIC.

CONCLUSION:

IL-1β, IL-6, and TNF-α in SIC patients rise markedly. The combined detection of the three has a better predictive value for patients with SIC and is closely related to the patients' prognoses, so it may be crucial in diagnosing and treating the disease.

• Authors: Peng Deng, Nana Tang, Lin Li, Guohui Zou, Yang Xu, Zhongyong Liu
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 158 Issue 9 Pg. 413-417 (05 13 2022) ISSN: 1578-8989 [Electronic] Spain
• PMID: 34147250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

Chemical References

• Cytokines
• IL1B protein, human
• IL6 protein, human
• Interleukin-1beta
• Interleukin-6
• Tumor Necrosis Factor-alpha

Topics

• Cardiomyopathies (diagnosis, etiology)
• Cytokines
• Humans
• Interleukin-1beta
• Interleukin-6
• Sepsis (complications, diagnosis)
• Tumor Necrosis Factor-alpha