Enhanced serum interferon-lambda 1 interleukin-29 levels in patients with psoriasis vulgaris.

Abstract

BACKGROUND:

Interferon (IFN)-λ1, also named Interleukin (IL)-29, is a new member of the Type III IFN or IFN-λ family. IL-29 plays an important role in the pathogenesis of many types of autoimmune and inflammatory diseases.

OBJECTIVE:

To study the role of IL-29 in the pathogenesis of psoriasis vulgaris.

METHODS:

The authors detected the serum levels of IL-29 in forty-one patients with psoriasis vulgaris, twenty-three patients with atopic dermatitis and thirty-eight age and gender-matched controls by sandwich Enzyme-Linked Immunosorbent Assay (ELISA). The effects of IL-29 on the expression of cytokines, such as IL-6, IL-17, IL-8, IL-4, IL10, Interferon (IFN-γ) and Tumor Necrosis Factor-α (TNF-α), in PBMCs and HaCat cells were determined by real-time quantitative PCR.

RESULTS:

Our data indicated that serum IL-29 levels were significantly elevated in patients with psoriasis vulgaris when compared with atopic dermatitis patients and the control group. Moreover, Serum levels of IL-29 were closely associated with the severity of psoriasis vulgaris. Furthermore, IL-29 up-regulated the mRNA expression levels of IL-6, IL-17 and TNF-α in PBMCs from psoriasis vulgaris patients. In addition, IL-29 enhanced the IL-6 and IL-8 expression from the HaCat cells.

CONCLUSION:

This study provides the first observations on the association of IL-29 and psoriasis vulgaris and showed elevated IL-29 serum levels. The authors suggest that IL-29 may play a role in the pathogenesis of psoriasis vulgaris.

• Authors: Li-Xin Fu, Tao Chen, Zai-Pei Guo, Na Cao, Li-Wen Zhang, Pei-Mei Zhou
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2021 Jul-Aug Vol. 96 Issue 4 Pg. 416-421 ISSN: 1806-4841 [Electronic] Spain
• PMID: 34030913 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. All rights reserved.

Chemical References

• Cytokines
• interferon-lambda, human
• Interleukins
• Interferon-gamma
• Interferons

Topics

• Cytokines
• Humans
• Interferon-gamma
• Interferons
• Interleukins
• Leukocytes, Mononuclear
• Psoriasis