Abstract | BACKGROUND: METHODS: The outcomes of patients with OPSCC treated with IC followed by concurrent chemoradiation (CRT) were compared with the outcomes of those treated with CRT alone. The primary outcome was overall survival (OS), and the secondary end points were the times to locoregional and distant recurrence. RESULTS: In an existing database, 585 patients met the inclusion criteria: 137 received IC plus CRT, and 448 received CRT. Most patients were positive for human papillomavirus (HPV; 90.9%). Patients receiving IC were more likely to present with a higher T stage, a higher N stage, and low neck disease. The 3-year OS rate was significantly lower in patients receiving IC (75.7%) versus CRT alone (92.9%). In a multicovariate analysis, receipt of IC (adjusted hazard ratio [aHR], 3.4; P < .001), HPV tumor status (aHR, 0.36; P = .002), and receipt of concurrent cetuximab (aHR, 2.7; P = .002) were independently associated with OS. The risk of distant metastasis was also significantly higher in IC patients (aHR, 2.8; P = .001), whereas an HPV-positive tumor status (aHR, 0.44; P = .032) and completion of therapy (aHR, 0.51; P = .034) were associated with a lower risk of distant metastasis. In HPV-positive patients, IC remained associated with distant metastatic progression (aHR, 2.6; P = .004) but not OS. CONCLUSIONS: In contrast to prior studies, IC was independently associated with worse OS and a higher risk of distant metastasis in patients with OPSCC. Future studies are needed to validate these findings.
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Authors | Theresa W Guo, Faiez Saiyed, Christopher M K L Yao, Kimberley L Kiong, Julian Martinez, Ruth Sacks, J Jack Lee, Amy C Moreno, Steven J Frank, David I Rosenthal, Bonnie S Glisson, Renata Ferrarotto, Frank E Mott, Faye M Johnson, Jeffrey N Myers |
Journal | Cancer
(Cancer)
Vol. 127
Issue 16
Pg. 2916-2925
(08 15 2021)
ISSN: 1097-0142 [Electronic] United States |
PMID | 33873251
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 American Cancer Society. |
Topics |
- Carcinoma, Squamous Cell
(pathology)
- Chemoradiotherapy
- Head and Neck Neoplasms
(drug therapy)
- Humans
- Induction Chemotherapy
- Oropharyngeal Neoplasms
(pathology)
- Squamous Cell Carcinoma of Head and Neck
(drug therapy)
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