Abstract | PURPOSE:
Endometriosis is a common, chronic gynecological disease that affects women's fertility potential. Dydrogesterone is an effective and safe drug that is under-utilized due to limited clinical research. The purpose of this evidence mapping is to identify, describe, and analyze the current available evidence regarding dydrogesterone for the treatment of endometriosis. MATERIALS AND METHODS: We performed a search in electronic databases: Medline, The Cochrane Library, EMBASE, PubMed, CNKI, Wanfang, VIP, and CBM. We also hand-searched google for relevant studies. Our primary outcomes included changes in pain relief including pelvic pain, dysmenorrhea, and dyspareunia. Secondary outcomes included pregnancy rate, frequency of analgesic use, and other reported outcomes according to specific settings in the studies. RESULTS: CONCLUSIONS: The amount and quality of evidence evaluating the effects of dydrogesterone for the treatment of endometriosis is generally very low. Limited evidence suggests that dydrogesterone may have some advantages over gestrinone, GnRH agonists, and other therapeutic interventions in treating endometriosis. However, this conclusion should be interpreted with caution.
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Authors | Chao Peng, Yan Huang, Yingfang Zhou |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 304
Issue 1
Pg. 231-252
(07 2021)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 33398505
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Progestins
- Dydrogesterone
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Topics |
- Cohort Studies
- Dydrogesterone
(therapeutic use)
- Endometriosis
(drug therapy)
- Female
- Humans
- Neoplasm Recurrence, Local
- Pregnancy
- Progestins
(therapeutic use)
- Quality of Life
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