Letrozole (Femara)

A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women.

Also Known As:

Networked: 2111 relevant articles (352 outcomes, 671 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Goldhirsch, Aron: 32 articles (02/2021 - 12/2005)
2.	Goss, Paul E: 30 articles (02/2022 - 06/2002)
3.	Gelber, Richard D: 28 articles (02/2021 - 12/2005)
4.	Colleoni, Marco: 26 articles (02/2021 - 02/2007)
5.	Ingle, James N: 25 articles (02/2022 - 09/2003)
6.	Coates, Alan S: 24 articles (02/2021 - 12/2005)
7.	Regan, Meredith M: 24 articles (02/2021 - 09/2007)
8.	Thürlimann, Beat: 24 articles (02/2021 - 12/2005)
9.	Dixon, J Michael: 23 articles (01/2020 - 06/2002)
10.	Evans, Dean B: 22 articles (10/2012 - 10/2003)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 04/01/2004 - "[Complete remission obtained with letrozole in a man with metastatic breast cancer]." 03/16/2010 - "We found that letrozole and ZA induce levels of apoptosis in breast cancer cells in vitro that are significantly greater compared with treatment with each drug alone. " 08/01/2007 - "In MA.17 at 30 months, postmenopausal patients with early stage breast cancer who received extended adjuvant letrozole (n = 2593) experienced a significant (42%) improvement in DFS regardless of nodal status (P < 0.001), and there was a significant (39%) improvement in as in node-positive patients (P = 0.04), compared with placebo. " 01/01/2007 - "At a median follow-up of 30 months, letrozole significantly improved disease-free survival (DFS; P<0.001), the primary end point, compared with placebo (hazard ratio [HR] for recurrence or contralateral breast cancer 0.58; 95% confidence interval [CI] 0.45, 0.76] P<0.001). " 11/08/2023 - "Letrozole also improved breast cancer-free interval and distant recurrences without improving overall survival. "
2.	Neoplasms (Cancer) 01/01/2019 - "To facilitate optimal dosing for such studies, we evaluated the plasma and brain pharmacokinetics (PK) of letrozole in NOD-scid gamma (NSG) mice, which are frequently employed for assessing efficacy against patient-derived tumor cells. " 01/15/1993 - "Seven (33%, 95% confidence interval, 15-57%) of the 21 patients have responded to treatment (one complete remission, 6 partial remissions according to criteria of the Union Internationale contre le Cancer), and 6 are still responding to CGS 20267 (duration of response; 4+, 6+, 6+, 9+, 9, 12+, and 12+ months). " 03/01/2011 - "ENT plus letrozole also prevented lung colonization and growth of tumor cells, with a significant reduction (P > 0.03) in both visible and microscopic foci. " 01/01/2007 - "Furthermore, letrozole significantly improved distant DFS (HR=0.60; 95% CI 0.43, 0.84; P=0.002) and, in women with node-positive tumors, overall survival (HR=0.61; 95% CI 0.38, 0.98; P=0.04). " 08/24/2005 - "Disease-free survival was significantly improved with letrozole vs placebo, irrespective of whether patients had lymph node-positive or node-negative tumors. "
3.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 11/22/2023 - "Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome." 01/01/2023 - "The present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in a letrozole-induced mouse model of polycystic ovary syndrome (PCOS). " 09/22/2022 - "Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats." 01/01/2022 - "To investigate the efficacy of oral letrozole (LE) starting on day 3 or 5 of the menstrual cycle in patients with polycystic ovary syndrome (PCOS). " 11/29/2021 - "Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats."
4.	Neoplasm Metastasis (Metastasis) 10/01/2009 - "Letrozole also significantly reduces the occurrence of early distant metastases, the most lethal type of recurrence event, which can lead to improved survival. " 02/01/2013 - "(ECOG: 3) Letrozole was added in the treatment and we obtained near-complete remission from her lung and brain metastasis with 2.5 mg/day dose of letrozole. " 12/01/2008 - "Extended adjuvant letrozole reduced the risk of recurrence by 42% and the risk of distant metastases by 40%, it was well tolerated compared to placebo; among lymph node-positive patients, overall survival was significantly improved. " 01/01/2016 - "In conclusion, BC-inoculated OVX animals had higher tibia pathology scores than BC-inoculated intact animals and letrozole reduced BC metastases to lungs. " 03/01/2011 - "After careful examination, the patient was diagnosed as having multiple bone metastases and her medication was changed to oral letrozole. "
5.	Infertility (Sterility) 11/05/2019 - "In women with PCOS, letrozole improves live birth and clinical pregnancy rates and reduces time-to-pregnancy compared to CC and therefore can be recommended as the preferred first-line treatment for women with PCOS and infertility. " 01/01/2022 - "We included randomized controlled trials (RCTs) comparing IUI-OS with gonadotrophins, letrozole and CC among couples with unexplained infertility. " 07/01/2021 - "To study the feasibility of a randomized controlled trial (RCT) comparing intrauterine insemination (IUI) with and without letrozole in couples with unexplained or mild male factor infertility STUDY DESIGN: We performed a randomized pilot study including 100 couples with unexplained or mild male factor infertility in the Reproductive Medicine Centre of Peking University Third Hospital in China. " 01/01/2020 - "We included randomized controlled trials that compared a stimulation regimen with CC, Letrozole or gonadotrophins to each other or to natural cycle IUI among couples with unexplained infertility. " 12/01/2018 - "The results of this study demonstrate the stability of letrozole compared to that of CC for infertility treatment in pregnant women."

Related Drugs and Biologics

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2.	Aromatase Inhibitors
3.	Hormones (Hormone)
4.	Anastrozole (Arimidex)
5.	palbociclib
6.	Estrogen Receptors
7.	exemestane (Aromasin)
8.	Clomiphene (Clomifene)
9.	ribociclib
10.	ErbB Receptors (EGF Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Neoadjuvant Therapy
4.	Aftercare (After-Treatment)
5.	Chemoprevention