In late December 2019, the outbreak of respiratory illness emerged in Wuhan, China, and spreads worldwide. World Health Organization (WHO) named this disease severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused by a new member of beta coronaviruses. Several medications are prescribed to patients, and some clinical trials are underway. Scientists are trying to find a specific drug against this virus. In this review, we summarize the pathogenesis, clinical features, and current treatments of
coronavirus disease 2019 (COVID-19). Then, we describe the possible
therapeutic effects of
curcumin and its molecular mechanism against coronavirus-19.
Curcumin, as an active constituent of Curcuma longa (turmeric), has been studied in several experimental and clinical trial studies.
Curcumin has some useful clinical effects such as
antiviral, antinociceptive, anti-inflammatory,
antipyretic, and antifatigue effects that could be effective to manage the symptoms of the infected patient with
COVID-19. It has several molecular mechanisms including
antioxidant, antiapoptotic, and antifibrotic properties with inhibitory effects on
Toll-like receptors, NF-κB, inflammatory
cytokines and
chemokines, and
bradykinin. Scientific evidence suggests that
curcumin could have a potential role to treat
COVID-19. Thus, the use of
curcumin in the clinical trial, as a new treatment option, should be considered.