Chronic
joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an
arthritis patient.
Antioxidant compounds could solve the problems in arthritic condition. The objective of this study was to evaluate the anti-arthritic activity of D-
carvone against complete
Freund's adjuvant (CFA)-induced
arthritis in rats. D-
carvone was orally administered for 25 days at the doses of 30 and 60 mg/kg against CFA-induced arthritic rats. Changes in
body weight, paw swelling, organ index, hematological parameters, oxidative stress markers, inflammatory
cytokines, and histopathology were recorded. Oral treatment of D-
carvone significantly improved the
body weight, reduced the paw swelling,
edema formation, and organ index in arthritic rats. The levels of white blood cells were reduced, red blood cells and
hemoglobin levels were improved in D-
carvone treated arthritic rats. Lipid peroxidation levels were lowered whereas enzymatic and non-enzymatic
antioxidants were significantly elevated by D-
carvone administration against arthritic rats. D-
carvone significantly modulated inflammatory
cytokine levels and improved the ankle joint pathology against CFA-induced arthritic
inflammation. In conclusion, D-
carvone proved significant anti-arthritic activity against CFA-induced
arthritis in rats.