Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis.

Abstract

OBJECTIVES:

This study aimed to expand knowledge about soluble low-density lipoprotein receptor-related protein 1 (sLRP1) in juvenile idiopathic arthritis (JIA) by determining associations of sLRP1 levels in nonsystemic JIA patients with clinical and inflammatory biomarker indicators of disease activity.

METHODS:

Plasma sLRP1 and 44 inflammation-related biomarkers were measured at enrollment and 6 months later in a cohort of 96 newly diagnosed Canadian patients with nonsystemic JIA. Relationships between sLRP1 levels and indicators of disease activity and biomarker levels were analyzed at both visits.

RESULTS:

At enrollment, sLRP1 levels correlated negatively with age and active joint counts. Children showed significantly higher levels of sLRP1 than adolescents (mean ranks: 55.4 and 41.9, respectively; P = 0.02). Participants with 4 or fewer active joints, compared to those with 5 or more active joints, had significantly higher sLRP1 levels (mean ranks: 56.2 and 40.7, respectively; P = 0.006). At enrollment, considering the entire cohort, sLRP1 correlated negatively with the number of active joints (r = -0.235, P = 0.017). In the entire cohort, sLRP1 levels at enrollment and 6 months later correlated with 13 and 6 pro- and antiinflammatory biomarkers, respectively. In JIA categories, sLRP1 correlations with inflammatory markers were significant in rheumatoid factor-negative polyarticular JIA, oligoarticular JIA, enthesitis-related arthritis, and psoriatic arthritis at enrollment. Higher sLRP1 levels at enrollment increased the likelihood of absence of active joints 6 months later.

CONCLUSION:

Plasma sLRP1 levels correlate with clinical and biomarker indicators of short-term improvement in JIA disease activity, supporting sLRP1 as an upstream biomarker of potential utility for assessing JIA disease activity and outcome prediction.

• Authors: Elham Rezaei, Marianna M Newkirk, Zhenhong Li, John R Gordon, Kiem G Oen, Susanne M Benseler, Gilles Boire, David A Cabral, Sarah Campillo, Gaëlle Chédeville, Anne-Laure Chetaille, Paul Dancey, Ciaran Duffy, Karen Watanabe Duffy, Kristin Houghton, Adam M Huber, Roman Jurencak, Bianca Lang, Kimberly A Morishita, Ross E Petty, Suzanne E Ramsey, Johannes Roth, Rayfel Schneider, Rosie Scuccimarri, Lynn Spiegel, Elizabeth Stringer, Shirley M L Tse, Lori B Tucker, Stuart E Turvey, Rae S M Yeung, Alan M Rosenberg, Alan M. Rosenberg for the BBOP Study Group
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 48 Issue 5 Pg. 760-766 (05 2021) ISSN: 0315-162X [Print] Canada
• PMID: 33060303 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 by the Journal of Rheumatology.

Chemical References

• Lipoproteins, LDL
• Low Density Lipoprotein Receptor-Related Protein-1

Topics

• Adolescent
• Arthritis, Juvenile (diagnosis)
• Arthritis, Psoriatic
• Canada
• Child
• Humans
• Lipoproteins, LDL
• Low Density Lipoprotein Receptor-Related Protein-1