Astragaloside IV alleviates placental oxidative stress and inflammation in GDM mice.

Abstract

BACKGROUND:

Our previous study revealed that astragaloside IV (AS-IV) effectively improved gestational diabetes mellitus (GDM) by reducing hepatic gluconeogenesis. Due to the importance of placental oxidative stress, we further explored the protective role of AS-IV on placental oxidative stress in GDM.

METHODS:

First, non-pregnant mice were orally administrated with AS-IV to evaluate its safety and effect. Then GDM mice were orally administered with AS-IV for 20 days and its effect on the symptoms of GDM, placental oxidative stress, secretions of inflammatory cytokines, as well as toll-like receptor 4 (TLR4)/NF-κB signaling pathway, were evaluated.

RESULTS:

AS-IV had no adverse effect on non-pregnant mice. On the other hand, AS-IV significantly attenuated the GDM-induced hyperglycemia, glucose intolerance, insulin resistance, placental oxidative stress, productions of inflammatory cytokines and the activation of TLR4/NF-κB pathway.

CONCLUSION:

AS-IV effectively protected against GDM by alleviating placental oxidative stress and inflammation, in which TLR4/NF-κB might be involved.

• Authors: Ling Zhou, Ruixue Zhang, Shuangyan Yang, Yaguang Zhang, Dandan Shi
• Journal: Endocrine connections (Endocr Connect) Vol. 9 Issue 9 Pg. 939-945 (Oct 2020) ISSN: 2049-3614 [Print] England
• PMID: 33006955 (Publication Type: Journal Article)