Abstract | INTRODUCTION: CASE REPORT: MANAGEMENT & OUTCOME: Intradermal skin testing with rituximab at the concentration 1 mg/ml (dilution 1:10), was positive. Desensitization to rituximab was indicated by our service with 4 bags - 16 steps protocol with an initial concentration dose of 1/1,000 of the total dose. The patient was premedicated 1 hour prior with intravenous chlorphenamine, methylprednisolone and ondansetron. Intravenous prophylactic fluids with normal saline solution were administered during the infusion. The procedure was carried out with close monitoring of vital signs in a course of 6.67 hours, without presenting hypersensitivity reactions. DISCUSSION: HSR to rituximab may be induced by the activation of mast cells and basophils. Desensitization protocols are developed when there is no alternative drug for the underlying condition.
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Authors | Rosalaura V Villarreal-González, Cindy E de Lira-Quezada, Sandra N González-Díaz, Ligia L Carrasco-Díaz, Oscar González-Llano |
Journal | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
(J Oncol Pharm Pract)
Vol. 27
Issue 3
Pg. 747-750
(Apr 2021)
ISSN: 1477-092X [Electronic] England |
PMID | 32787558
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents, Immunological
- Rituximab
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Topics |
- Anaphylaxis
(chemically induced, diagnosis, immunology)
- Antineoplastic Agents, Immunological
(administration & dosage, adverse effects)
- Child
- Desensitization, Immunologic
(methods)
- Drug Hypersensitivity
(diagnosis, immunology)
- Female
- Humans
- Pilot Projects
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(diagnosis, drug therapy, immunology)
- Rituximab
(administration & dosage, adverse effects)
- Severity of Illness Index
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