Novel immune biomarkers in complex regional pain syndrome.

Abstract

We investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with positive correlations between kynurenine/tryptophan ratio and TNF-α levels with kinesiophobia, tetrahydrobiopterin levels with McGill pain score, sRAGE, and xanthurenic acid and neopterin levels with depression, anxiety and stress scores. Using machine learning, we identified a set of binary variables, including IL-37 and GM-CSF, capable of distinguishing controls from established CRPS subjects. These results suggest possible involvement of various inflammatory markers in CRPS pathogenesis.

• Authors: Marc A Russo, Peter Georgius, Ananda Staats Pires, Benjamin Heng, Michael Allwright, Boris Guennewig, Danielle M Santarelli, Dominic Bailey, Nathan T Fiore, Vanessa X Tan, Alexandra Latini, Gilles J Guillemin, Paul J Austin
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 347 Pg. 577330 (10 15 2020) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 32731051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• IL37 protein, human
• Interleukin-1
• Tumor Necrosis Factor-alpha
• Kynurenine
• Tryptophan

Topics

• Adult
• Aged
• Biomarkers (blood)
• Complex Regional Pain Syndromes (blood, diagnosis, immunology)
• Female
• Humans
• Interleukin-1 (blood, immunology)
• Kynurenine (blood, immunology)
• Machine Learning
• Male
• Middle Aged
• Pilot Projects
• Tryptophan (blood, immunology)
• Tumor Necrosis Factor-alpha (blood, immunology)