Abstract | BACKGROUND: METHODS:
Bleomycin intratracheal administration was performed on the first day and for the following twenty-one days, mice were treated with adelmidrol (10 mg/Kg). RESULTS: The survival rate and body weight gain were recorded daily. At the end of the experiment, adelmidrol-administered animals showed reduced airway infiltration by inflammatory cells, Myeloperoxidase (MPO) activity, and pro-inflammatory cytokine overexpression (IL,6 IL-1β, TNF-α, and TGF-1β). Moreover, adelmidrol treatment was able to manage the significant incapacity of antioxidants and elevation of the oxidant burden, as shown by the MDA, SOD, and GSH levels and decreased nitric oxide production. It was also able to significantly modulate the JAK2/STAT3 and IκBα/ NF-kB pathway. Histologic examination of the lung tissues showed reduced sample injury, mast cell degranulation, chymase activity, and collagen deposition. CONCLUSIONS:
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Authors | Roberta Fusco, Marika Cordaro, Tiziana Genovese, Daniela Impellizzeri, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Ramona D'Amico, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola |
Journal | Antioxidants (Basel, Switzerland)
(Antioxidants (Basel))
Vol. 9
Issue 7
(Jul 09 2020)
ISSN: 2076-3921 [Print] Switzerland |
PMID | 32660140
(Publication Type: Journal Article)
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