Abstract | INTRODUCTION: Preoperative administration of nonsteroidal anti-inflammatory drugs has been suggested as a method for increasing the efficacy of local anesthetics and decreasing postoperative pain in symptomatic irreversible pulpitis cases. However, the effects of ibuprofen at the molecular level are still unknown. Hence, the purpose of this study was to compare the levels of proinflammatory mediators in the dental pulp of teeth with irreversible pulpitis in patients who medicated with preoperative ibuprofen versus those who did not. METHODS: RESULTS: CONCLUSIONS: The data showed that preoperative ibuprofen significantly decreased the levels of most proinflammatory cytokines in the dental pulp, which could possibly help with anesthesia in irreversible cases.
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Authors | Vicky Nguyen, Yen-Wei Chen, James D Johnson, Avina Paranjpe |
Journal | Journal of endodontics
(J Endod)
Vol. 46
Issue 9
Pg. 1210-1216
(Sep 2020)
ISSN: 1878-3554 [Electronic] United States |
PMID | 32565333
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Published by Elsevier Inc. |
Chemical References |
- Anesthetics, Local
- Anti-Inflammatory Agents, Non-Steroidal
- Ibuprofen
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Topics |
- Anesthesia, Dental
- Anesthetics, Local
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Double-Blind Method
- Humans
- Ibuprofen
(therapeutic use)
- Prospective Studies
- Pulpitis
(drug therapy)
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