Abstract | BACKGROUND: MATERIALS AND METHODS: Male C57BL/KsJ-db/db and C57BL/KsJ-db/+ mice at 4 weeks of age were divided into four groups (N=6/group): (1) NC (normal control - db/+ mice, 1% methylcellulose, intragastric administration), (2) DM (diabetic model - db/db mice, 1% methylcellulose, intragastric administration), (3) ATM 100 (DM + 100 mg/kg of artemether) and (4) ATM 200 (DM + 200 mg/kg of artemether). A number of assays related to diabetes were then performed following a 4-week period of these treatments. RESULTS: CONCLUSION:
Artemether may regulate glycolipid metabolism in db/db mice by improving the immune microenvironment. The results of this study provide important new information that can serve as the foundation for future research into the use of artemether as a means to improve glycolipid metabolism.
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Authors | Wei Fu, Yujin Ma, Liping Li, Jie Liu, Liujun Fu, Yu Guo, Zhiyin Zhang, Jiaxi Li, Hongwei Jiang |
Journal | Diabetes, metabolic syndrome and obesity : targets and therapy
(Diabetes Metab Syndr Obes)
Vol. 13
Pg. 1703-1713
( 2020)
ISSN: 1178-7007 [Print] New Zealand |
PMID | 32547132
(Publication Type: Journal Article)
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Copyright | © 2020 Fu et al. |