Atraumatic idiopathic splenic rupture induced by granulocyte-colony stimulating factor (G-CSF) for the treatment of pancytopenia, managed successfully by laparoscopic splenectomy.

Abstract

Splenic rupture is a potentially life-threatening condition and an uncommon short-term complication of granulocyte-colony stimulating factor (G-CSF) administration. It may present as acute abdominal pain or suddenly precipitously worsening anaemia with haemodynamic instability that requires urgent operative intervention for survival. We present a case of an atraumatic idiopathic splenic rupture in University Hospital, Ayr in a patient who received G-CSF treatment for chemotherapy-induced (methotrexate) pancytopenia and was successfully managed by laparoscopic splenectomy.

• Authors: Ugochukwu Chinyere Chinaka, Joshua Fultang, Jelizaveta Pereca, Abdulmajid Ali
• Journal: BMJ case reports (BMJ Case Rep) Vol. 13 Issue 4 (Apr 09 2020) ISSN: 1757-790X [Electronic] England
• PMID: 32276997 (Publication Type: Case Reports)
• Copyright: © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Female
• Granulocyte Colony-Stimulating Factor (adverse effects)
• Humans
• Laparoscopy
• Middle Aged
• Pancytopenia (drug therapy)
• Rupture, Spontaneous (etiology, surgery)
• Spleen (diagnostic imaging)
• Splenectomy
• Splenic Rupture (etiology, surgery)
• Treatment Outcome
• United Kingdom (epidemiology)