Protective effects of chondroitin sulphate nano-selenium on a mouse model of Alzheimer's disease.

Abstract

In this study, the effect of chondroitin sulphate nano-selenium (CS@Se) on Alzheimer's disease (AD) in mice was investigated. CS@Se alleviated anxiety and improved the spatial learning and memory impairment in AD mice. CS@Se significantly reduced cell oedema and pyknosis, protected the mitochondria, and improved abnormal changes in the ultrastructure of hippocampal neuron synapses of AD mice. Moreover, CS@Se significantly increased the levels of superoxide dismutase(SOD), glutathione peroxidase (GSH-Px), Na+/K+-ATPase assay (Na+/K+-ATPase) and acetyltransferase (ChAT), and decreased the levels of malondialdehyde (MDA) and acetylcholinesterase (ChAE) in AD mice. Western blot results showed that CS@Se can attenuate excessive phosphorylation of tau (Ser396/Ser404) by regulating the expression of glycogen synthase kinase-3 beta (GSK-3β). In addition, CS@Se can activate the extracellular signal-regulated kinase 1/2 (ERK 1/2) and p38 mitogen-activated protein kinase (p38 MAPK) signalling pathways to inhibit nuclear transcription factor kappa B (NF-κB) nuclear translocation, thereby regulating the expression of pro-inflammatory cytokines. In summary, CS@Se can reduce oxidative stress damage, inhibit excessive tau phosphorylation, reduce inflammation to delay AD development, and increase the learning and memory capacities of AD mice.

• Authors: Dongsheng Ji, Xiaming Wu, Delong Li, Ping Liu, Sitao Zhang, Debo Gao, Fei Gao, Mengxiao Zhang, Yuliang Xiao
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 154 Pg. 233-245 (Jul 01 2020) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 32171837 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Chondroitin Sulfates
• Selenium

Topics

• Alzheimer Disease (drug therapy)
• Animals
• Chondroitin Sulfates (therapeutic use)
• Hippocampus (drug effects, pathology)
• Male
• Memory (drug effects)
• Mice
• Mice, Inbred C57BL
• Nanoparticles (chemistry)
• Neurons (drug effects, pathology)
• Oxidative Stress (drug effects)
• Selenium (therapeutic use)
• Spatial Learning (drug effects)