Açarı C, Ünsal E, Hakgüder G, Soylu A, Özer E. Pediatric
mesenteric panniculitis: three cases and a review of the literature. Turk J Pediatr 2019; 61: 798-803.
Mesenteric panniculitis is an inflammatory and fibrotic process in the mesenteric adipose tissue with unknown etiology. It is rarely seen in general, particularly in children. Etiology is unknown, and pathophysiology is not clear. Factors that trigger the disease are
malignancy,
tuberculosis,
trauma, medications and past surgical interventions. There is no pediatric case series in the literature except single case reports. This paper consists of 3 cases: The first case is a 5-month-old girl, the youngest patient in the literature, who was referred to a pediatric surgeon with
vomiting and abdominal distention. She had diffused intraabdominal fluid and
mesenteric panniculitis documented by perioperative biopsy. The second case had acute
abdominal pain with
perforated appendicitis, who eventually had
mesenteric panniculitis in the evaluation of the pathological specimen. The last case had a diagnosis of
polyarticular juvenile idiopathic arthritis (JIA), successfully treated with
etanercept, and has been in remission for 2 years. Interestingly, in one of her routine visits, she had pallor,
anemia and
renal failure. Bilateral
hydronephrosis was detected. Magnetic resonance imaging (MRI) of the abdomen revealed
retroperitoneal fibrosis, and
mesenteric panniculitis was the histopathological diagnosis.