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Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.

Abstract
Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipopolysaccharide (LPS)-activated BV-2 cells. Our results demonstrated that treatment with baicalein remarkably restrained the production of pro-inflammatory factors including nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in LPS-activated BV-2 cells. Moreover, baicalein significantly inhibited reactive oxygen species (ROS) production, decreased cyclooxygenase-2 (COX-2) and nuclear factor-b (NF-κB)/p65 expression. 1H NMR metabolomics analysis revealed that 12 differential metabolites were regulated by baicalein, implicated in alanine, aspartate and glutamate metabolism, glutathione metabolism, arginine and proline metabolism, D-glutamine and D-glutamate metabolism. In conclusion, these results indicated that baicalein has protective and modulatory effects on neuroinflammation and oxidative stress in LPS-activated BV-2 cells.
AuthorsJiao-Jiao Yan, Guan-Hua Du, Xue-Mei Qin, Li Gao
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 79 Pg. 106092 (Feb 2020) ISSN: 1878-1705 [Electronic] Netherlands
PMID31863920 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Cytokines
  • Flavanones
  • Inflammation Mediators
  • Lipopolysaccharides
  • NF-kappa B
  • baicalein
  • Ptgs2 protein, mouse
  • Cyclooxygenase 2
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Cell Line
  • Cyclooxygenase 2 (metabolism)
  • Cytokines (metabolism)
  • Flavanones (pharmacology)
  • Gene Expression Regulation
  • Inflammation Mediators (metabolism)
  • Lipopolysaccharides (metabolism)
  • Metabolic Diseases (drug therapy)
  • Mice
  • Microglia (metabolism, pathology)
  • NF-kappa B (metabolism)
  • Neurogenic Inflammation (drug therapy)
  • Signal Transduction

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