Abstract |
Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis was associated with juvenile idiopathic arthritis. Uveitis predominately affected the anterior segment, was bilateral and recurrent. Complications were common and included visual loss, synechiae, cataract and/or retinal lesions. Patients received up to 5 IVMP at monthly intervals. Visual acuity improved at 3 and 6 months. Anterior chamber cells, synechiae, keratic precipitates, papillary and/or macular edema improved at 3 months. Children treated with ≥3 IVMP (vs 1 IVMP) experienced trends towards fewer relapses, fewer cataracts and less frequently required treatment with biologic agents. High-dose IVMP induce rapid improvement in children with non-infectious uveitis. Prospective randomized trials are required to confirm results.
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Authors | Anja Schnabel, Elisabeth Unger, Normi Brück, Reinhard Berner, Ursula Range, Annette Holl-Wieden, Henner Morbach, Anna Leszczynska, Viktoria Bau, Christian M Hedrich |
Journal | Clinical immunology (Orlando, Fla.)
(Clin Immunol)
Vol. 211
Pg. 108327
(02 2020)
ISSN: 1521-7035 [Electronic] United States |
PMID | 31863906
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Methylprednisolone
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Topics |
- Administration, Intravenous
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Arthritis, Juvenile
(drug therapy)
- Child
- Child, Preschool
- Female
- Humans
- Male
- Methylprednisolone
(therapeutic use)
- Retrospective Studies
- Treatment Outcome
- Uveitis
(drug therapy)
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