HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

High-dose intravenous methylprednisolone in juvenile non-infectious uveitis: A retrospective analysis.

Abstract
Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis was associated with juvenile idiopathic arthritis. Uveitis predominately affected the anterior segment, was bilateral and recurrent. Complications were common and included visual loss, synechiae, cataract and/or retinal lesions. Patients received up to 5 IVMP at monthly intervals. Visual acuity improved at 3 and 6 months. Anterior chamber cells, synechiae, keratic precipitates, papillary and/or macular edema improved at 3 months. Children treated with ≥3 IVMP (vs 1 IVMP) experienced trends towards fewer relapses, fewer cataracts and less frequently required treatment with biologic agents. High-dose IVMP induce rapid improvement in children with non-infectious uveitis. Prospective randomized trials are required to confirm results.
AuthorsAnja Schnabel, Elisabeth Unger, Normi Brück, Reinhard Berner, Ursula Range, Annette Holl-Wieden, Henner Morbach, Anna Leszczynska, Viktoria Bau, Christian M Hedrich
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 211 Pg. 108327 (02 2020) ISSN: 1521-7035 [Electronic] United States
PMID31863906 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Elsevier Inc. All rights reserved.
Chemical References
  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Methylprednisolone
Topics
  • Administration, Intravenous
  • Adolescent
  • Adrenal Cortex Hormones (therapeutic use)
  • Anti-Inflammatory Agents (therapeutic use)
  • Arthritis, Juvenile (drug therapy)
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Methylprednisolone (therapeutic use)
  • Retrospective Studies
  • Treatment Outcome
  • Uveitis (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: