Objective: To evaluate the risk of activation of
latent tuberculosis infection (LTBI) in Chinese patients with
rheumatic diseases who have received
glucocorticoid treatment.Methods: We conducted a 2-year study, enrolling 1788 patients with
rheumatic diseases who were treated with
glucocorticoid for at least 4 weeks at the Department of Immunology and Rheumatology, First Affiliated Hospital of Nanchang University.
Interferon-release assays (IGRA) were performed with patient blood samples obtained at baseline. Patient data, including age, gender, body mass index (BMI), duration and dosage of
glucocorticoid and
disease-modifying antirheumatic drug (
immunosuppressant) treatment and comorbidities (
malignancies, diabetes,
chronic renal failure,
silicosis) were collected. Patients were followed for 2 years to detect the emergence of active
tuberculosis (TB).Results: 21.8% (349/1600) of the patients tested positive in IGRA, indicating LTBI. 2-year follow-up showed that 18 (5.16%) patients with positive IGRA but only 4 (0.35%) patients with negative IGRA developed active TB (p < .05). SLE patients had the highest activation rate of 2.22 per 100 total recruitment cases/year. Univariate and multivariate analysis showed that low BMI(<18.5), administration of high dose
glucocorticoids (>15 mg daily), and comorbidities that included
interstitial lung disease and malignant
cancers were significantly associated with LTBI activation.Conclusion: Our results suggest that screening and preventive
therapy of LTBI may be advisable for Chinese
rheumatic disease and particularly SLE patients undergoing
glucocorticoid therapy with dosage above 15 mg
prednisone equivalent daily for more than 4 weeks.