Efficacy of preemptive analgesia versus postoperative analgesia of celecoxib on postoperative pain, patients' global assessment and hip function recovery in femoroacetabular impingement patients underwent hip arthroscopy surgery.

Abstract

We aimed to investigate the efficacy of preemptive analgesia of celecoxib on postoperative pain, patients' global assessment (PGA) and hip function recovery compared to postoperative analgesia of celecoxib in femoroacetabular impingement (FAI) patients who underwent hip arthroscopy surgery (HAS). The 100 FAI patients underwent HAS were randomly allocated to preemptive analgesia group (N = 50) or postoperative analgesia group (N = 50) as a 1:1 ratio for 3 months. Pain visual analog scale (VAS) score, PGA score, rescue-use pethidine consumption and Harris hip score were assessed. Compared to postoperative analgesia group, pain VAS score decreased on day 1 (P = 0.036), day 2 (P = 0.046) and day 3 (P = 0.046), while was similar prior to operation (P = 0.587), on day 7 (P = 0.398), at month 1 (P = 0.461) and month 3 (P = 0.805) in preemptive analgesia group. Besides, rescue-use pethidine consumption was decreased in preemptive analgesia group than postoperative analgesia group within 3 days (P = 0.016) and within 7 days (P = 0.033) post-operation. For PGA score, it reduced on day 2 (P = 0.030) and day 3 (P = 0.048), while was similar prior to operation (P = 0.699), on day 1 (P = 0.699), day 7 (P = 0.224), at month 1 (P = 0.640) and month 3 (P = 0.400) in preemptive analgesia group than postoperative analgesia group. For Harris hip score, it was similar prior to operation (P = 0.372), on day 7 (P = 0.366), at month 1 (P = 0.466) and month 3 (P = 0.658) between the two groups. In conclusion, preemptive analgesia of celecoxib decreases short-term postoperative pain and PGA, but without effect on long-term hip function recovery than postoperative analgesia of celecoxib in FAI patients who underwent HAS.

• Authors: Xiaoping Zhu
• Journal: Inflammopharmacology (Inflammopharmacology) Vol. 28 Issue 1 Pg. 131-137 (Feb 2020) ISSN: 1568-5608 [Electronic] Switzerland
• PMID: 31595391 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cyclooxygenase 2 Inhibitors
• Celecoxib

Topics

• Adult
• Arthroscopy (methods)
• Celecoxib (administration & dosage)
• Cyclooxygenase 2 Inhibitors (administration & dosage)
• Female
• Femoracetabular Impingement (surgery)
• Hip Joint (surgery)
• Humans
• Male
• Pain Measurement
• Pain, Postoperative (prevention & control)
• Recovery of Function
• Time Factors
• Treatment Outcome